BETO establishes Agile BioFoundry to streamline biomanufacturing

October 11, 2016

BY U.S. Department of Energy

On Oct. 1, the U.S. Department of Energy’s Bioenergy Technologies Office established the Agile BioFoundry—a new consortium of nine Energy Department national laboratories working to standardize and streamline the entire biomanufacturing pipeline by uniting computer-assisted biological pathway design, process integration, process scale-up, and machine learning. 

Lawrence Berkeley National Laboratory is leading the consortium. The national laboratories have a unique capability to provide facilities and tools and to share the cumulative knowledge gained to accelerate progress in both public and private sectors. This coordinated public effort will aid in efficiently realizing BETO’s goal to commercialize biofuels and renewable chemicals. 

The ABF, with $35 million requested for fiscal year 2017, will achieve its goals by developing a system for product development and commercialization that will be broadly applicable to many bioproducts. The system will be an iterative Design-Build-Test-Learn process that involves the following: 

Design—Selecting microorganisms and biochemical pathways through integrated analysis, and planning how to achieve increased product output using computer-assisted design

Advertisement

Build—Using molecular biology tools and laboratory automation to generate collections of microbial strains to be tested for improved performance

Test—Evaluating the strains generated using a multi-omics approach and process integration

Learn—Compiling the results to inform future experiments using advanced statistical algorithms and machine learning. 

The ABF hopes to achieve a 40 percent reduction in energy intensity and 60 percent reduction in carbon intensity over current manufacturing processes, and also has a goal of reducing product time to market by 50 percent. The ABF plans to serve as a resource for data, software tools, analytical and biological protocols, and economic analyses, disseminating information through its website. In addition, the ABF will seek to actively partner with industry to ensure that the latest developments in synthetic biology are broadly accessible, enabling bio-derived products to reach the market more quickly.

Advertisement

Development of the ABF is part of BETO’s Conversion Research and Development Program, which funds projects to develop technologies for converting biomass feedstocks into viable biofuels and bioproducts, moving toward an economically competitive and environmentally sustainable bioeconomy.

 

 

 

 

Related Stories

The U.S. EPA on July 8 hosted virtual public hearing to gather input on the agency’s recently released proposed rule to set 2026 and 2027 RFS RVOs. Members of the biofuel industry were among those to offer testimony during the event.

Read More

The USDA’s Risk Management Agency is implementing multiple changes to the Camelina pilot insurance program for the 2026 and succeeding crop years. The changes will expand coverage options and provide greater flexibility for producers.

Read More

EcoCeres Inc. has signed a multi-year agreement to supply British Airways with sustainable aviation fuel (SAF). The fuel will be produced from 100% waste-based biomass feedstock, such as used cooking oil (UCO).

Read More

President Trump on July 4 signed the “One Big Beautiful Bill Act.” The legislation extends and updates the 45Z credit and revives a tax credit benefiting small biodiesel producers but repeals several other bioenergy-related tax incentives.

Read More

CARB on June 27 announced amendments to the state’s LCFS regulations will take effect beginning on July 1. The amended regulations were approved by the agency in November 2024, but implementation was delayed due to regulatory clarity issues.

Read More

Upcoming Events

Sign up for our e-newsletter!

Advertisement

Advertisement